1, Tomiya-cho

Cho 1 Statistic Literature Review – OLS Regression

1. A brief summary of the statistical method (1) What is the method? Regression is a statistical technique used for modeling and analysis of numerical data by finding the best-fitting straight line. In other words, a regression line is defined the combination between the average values of a numerical outcome variable and deterministic variables. The ways to find a best fitting straight line, es...

Production and purification of TGFb-1 in CHO-Cells

Introduction The development of chemically well defined media is a demanding task in order to create the optimal conditions for an in vitro stem cell (SC) proliferation and differentiation system. Signals that govern SC differentiation into multiple mature cell types are provided by growth factors. TGFb-1 regulates a number of biological processes, including cell differentiation and proliferati...

Cho 8_8

As no standard chemotherapy regimen has been established for advanced gastric cancer, this study sought to evaluate the efficacy and safety of combination chemotherapy that included paclitaxel and leucovorin (LV)-modulated infusional 5-fluorouracil (5-FU) in metastatic gastric cancer. Patients received a three-hour infusion of 175 mg/m2 of paclitaxel on day 1. A bolus of 20 mg/m2 of LV was then...

Expression of Recombinant Alpha-1 Antitrypsin in CHO and COS-7 Cell Lines Using Lentiviral Vector

In this study, in order to facilitate and accelerate the production of eukaryotic protein alpha 1-antitrypsin (AAT) with correct post-translational modifications, a protein production system based on the transduction of CHO and COS-7 cells using lentiviral vectors was developed. Human AAT cDNA was cloned into a replication-defective lentiviral vector. The transgene AAT-Jred chimer was transferr...

Won - Seob Cho 2005